Key differences Between Schedule I and Schedule III — What Rescheduling Marijuana Could Mean Schedule I vs Schedule III Under the U.S. Controlled Substances Act (CSA), drugs are classified into schedules based on their accepted medical use, potential for abuse, and risk of dependence. Two key schedules in this context are Schedule I and Schedule III: Schedule I : Drugs with no currently accepted medical use in the U.S., a high potential for abuse , and potentially severe psychological or physical dependence. Examples include heroin, LSD, and currently, marijuana (cannabis). Schedule III : Drugs with accepted medical use , moderate to low potential for physical and psychological dependence, and a lower abuse risk compared to Schedules I or II. Examples include ketamine, anabolic steroids, testosterone, and certain codeine combinations (like Tylenol with codeine). Rescheduling marijuana from Schedule I to Schedule III would formally recognize its medical benefits...
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