Skip to main content

Endocannabinoid System Series

Endocannabinoid System Series Summary


The series explores the intricate Endocannabinoid System (ECS), the body’s own biochemical network that maintains balance, or homeostasis. Across six posts, it breaks down the ECS into digestible parts:


1. Introduction to the ECS – Overview of how the ECS regulates mood, appetite, sleep, immune response, and pain through endocannabinoids and receptors.



2. Cannabinoid Receptors (CB1 & CB2) – Detailed look at receptor locations and roles: CB1 primarily in the brain and nervous system, CB2 in the immune system and peripheral organs.



3. Endocannabinoids Explained – Focus on key molecules like anandamide and 2-AG, how the body produces them, and their impact on physiological processes.



4. Interaction with Phytocannabinoids – How plant-derived cannabinoids like THC and CBD mimic or modulate ECS activity, and their therapeutic potential.



5. ECS and Health – ECS involvement in stress, inflammation, neurological disorders, and overall wellness, including potential for clinical applications.



6. Optimizing Your ECS – Lifestyle, diet, and supplementation strategies to support ECS function and improve balance naturally.




Series Takeaway: The ECS is a vital, often overlooked system influencing nearly every aspect of human health. Understanding it empowers readers to make informed decisions about lifestyle, wellness, and cannabis.

Comments

People's Choice

A Thank You Letter To President Trump for Opening the Door to Cannabis Research

  Trump's Cannabis From Schedule I to Schedule III Move Dear President Trump, I want to extend a sincere and enthusiastic thank you for your leadership in considering and moving forward with the rescheduling of marijuana from a Schedule I to a Schedule III controlled substance — a step that has already begun to reshape the national conversation around cannabis, research, and medical science. Your public remarks acknowledging that many people want this reclassification because it “leads to tremendous amounts of research that can’t be done unless you reclassify” reflect a willingness to look beyond old stigmas and recognize the potential for science and medicine to understand cannabis more fully. This shift — which would acknowledge cannabis as a substance with accepted medical use and a lower potential for abuse relative to Schedule I drugs — marks one of the most significant federal policy considerations in decades. By opening the door to research, innovation, an...

What Is Nerolidol?

  Because of its sedative qualities, nerolidol-rich strains are often favored for evening use or for relaxation. What Is Nerolidol? Nerolidol is a naturally occurring sesquiterpene found in many plants. It has a distinctive aroma described as woody, floral, and slightly citrusy, often reminiscent of fresh ginger, jasmine, or bark. This terpene is known for its calming, sedative qualities and is commonly used in perfumes, cosmetics, and traditional herbal medicines. Nerolidol in Cannabis In cannabis, nerolidol contributes a subtle, complex aroma that blends woodsy and floral notes. It’s less common than some other terpenes but plays an important role in the overall scent and effect profile of certain strains. Strains high in nerolidol tend to be: Woody and floral Earthy with a touch of citrus Smooth and mellow Nerolidol itself does not produce intoxication but interacts with cannabinoids like THC and CBD to shape the overall experience. Effects Commo...

The Cannabis Beverage Revolution: How THC Drinks Are Disrupting Big Alcohol (And Why Tennessee Shut Them Down)

THC-infused beverages are rapidly replacing alcohol for many consumers—triggering a coordinated backlash from the alcohol industry  that culminated in Tennessee’s 2025 hemp crackdown. The Cannabis Beverage Revolution: How THC Drinks Are Disrupting Big Alcohol (And Why Tennessee Shut Them Down) A Deep Dive Into the Fastest-Growing Segment of the Cannabis Industry—And the Billion-Dollar Threat That Triggered Tennessee's Crackdown Jump to: Market Explosion Alcohol Industry Threat Big Alcohol's Response Tennessee's Response Product Reality Health Comparison Market Reality Federal Complication Tennessee's Position The Future Conclusion When Tennessee transferred hemp regulation to the Tennessee Alcoholic Beverage Commission on January 1, 2026, most people assumed it was about public safety or protecting children. But the real story is far more revealing: it's about protecting the alcohol ind...

Border Economics: How Tennessee's Neighbors Are Profiting from Legal Cannabis While Tennessee Pays to Enforce Prohibition

  Border Economics: How Tennessee's Neighbors Are Profiting from Legal Cannabis While Tennessee Pays to Enforce Prohibition A Comparative Analysis of Cannabis Tax Revenue in Surrounding States On This Page What Tennessee’s Neighbors Are Earning Illinois: The Border State Boom Missouri: The Show-Me State Shows Results Arkansas: Medical Market, Real Revenue Virginia: The Complicated Case Tennessee’s Enforcement Costs The Opportunity Cost Tennessee as a Regional Outlier Cross-Border Commerce The Economic Multiplier Effect Comparing Tax Structures The Social Equity Argument What the Data Shows Conclusion: The Choice Before Tennessee While Illinois collected nearly $500 million in cannabis tax revenue in 2024 , Tennessee spent millions arresting and incarcerating people for marijuana possession. Both states have similar populations. One is funding schools and community programs; th...

Key differences Between Schedule I and Schedule III — What Rescheduling Marijuana Could Mean

  Key differences Between Schedule I and Schedule III — What Rescheduling Marijuana Could Mean Schedule I vs Schedule III Under the U.S. Controlled Substances Act (CSA), drugs are classified into schedules based on their accepted medical use, potential for abuse, and risk of dependence. Two key schedules in this context are Schedule I and Schedule III: Schedule I : Drugs with no currently accepted medical use in the U.S., a high potential for abuse , and potentially severe psychological or physical dependence. Examples include heroin, LSD, and currently, marijuana (cannabis). Schedule III : Drugs with accepted medical use , moderate to low potential for physical and psychological dependence, and a lower abuse risk compared to Schedules I or II. Examples include ketamine, anabolic steroids, testosterone, and certain codeine combinations (like Tylenol with codeine). Rescheduling marijuana from Schedule I to Schedule III would formally recognize its medical benefits...