11-hydroxy-THC is a metabolite your liver creates when it processes delta-9-THC

11-Hydroxy-THC: Why Edibles Hit So Differently

Understanding the metabolite behind the stronger, longer-lasting edible experience

---

If you’ve ever taken an edible and thought, “This feels nothing like smoking,” you’re not imagining things. The difference comes down to a compound called 11-hydroxy-THC.

When cannabis is eaten rather than inhaled, your body processes THC in a completely different way — and that changes both the intensity and duration of the experience.

What Is 11-Hydroxy-THC?

11-hydroxy-THC is a metabolite created by your liver when it processes delta-9-THC, the primary psychoactive compound in cannabis.

When THC is smoked or vaped, it enters the bloodstream directly through the lungs. When THC is eaten, it must first pass through the digestive system and the liver. This process is known as first-pass metabolism.

During this process, the liver converts delta-9-THC into 11-hydroxy-THC — a compound that behaves differently in the body and brain.

What Makes 11-Hydroxy-THC Different?

• More potent: Research suggests 11-hydroxy-THC may be 2–3 times more psychoactive than delta-9-THC.
• Crosses the blood-brain barrier more efficiently: This allows it to reach the brain more effectively.
• Stronger body effects: This contributes to the heavier, more physical sensation commonly associated with edibles.

This is why edible highs often feel more intense, more immersive, and sometimes more overwhelming compared to smoking or vaping.

Typical Strength & Timing Profile

While experiences vary, edible cannabis metabolized into 11-hydroxy-THC typically follows this general pattern:

• Onset: 30 minutes to 2 hours (sometimes longer)
• Peak: Around 2–4 hours after consumption
• Duration: 6–8 hours, sometimes longer
• Effects: More sedating, more body-focused, and often more psychedelic or introspective than inhaled THC

Many people describe edible effects as a “heavier” or “full-body” experience rather than the quicker, head-focused effects of smoking.

Why Edible Experiences Vary So Much

One of the biggest challenges with edibles is unpredictability. Several factors influence how much 11-hydroxy-THC your body produces:

• Genetics and liver enzyme activity
• Overall metabolism speed
• Body fat percentage
• What you’ve eaten (especially fats)
• Medications and supplements
• Individual tolerance and experience

Some people are fast metabolizers — they feel effects quickly and strongly, but the experience may fade sooner. Others are slow metabolizers and may feel delayed, muted, or inconsistent effects.

Because of first-pass metabolism, edible dosing is far less predictable than inhaled cannabis.

Why “Start Low and Go Slow” Matters

The classic edible advice exists for a reason.

Many people take more too soon, thinking the edible “isn’t working,” only to be overwhelmed later when 11-hydroxy-THC fully kicks in.

Starting with a low dose and waiting a full two hours before increasing helps prevent uncomfortable experiences and allows users to better understand their own metabolism.

---

Edibles don’t just last longer — they change how THC works in your body. 11-hydroxy-THC is the reason.

© Tennessee Cannabiz